An 82 year old man made the following statement:
"I look back on my life and ask what really happened? There are a lot of things I would have done differently, but I'm not sure what I could have changed given all my life circumstances."
I let him know we have all probably had similar thoughts over the years and was then able to re-direct him by letting him talk about all his many successes over his life (being a husband, father, having a successful career, etc.).
I think we BOTH felt better after that.